Structural insights into adrenergic receptor function and pharmacology
نویسندگان
چکیده
منابع مشابه
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
The beta2-adrenergic receptor (beta2AR) is a well-studied prototype for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters. To overcome the structural flexibility of the beta2AR and to facilitate its crystallization, we engineered a beta2AR fusion protein in which T4 lysozyme (T4L) replaces most of th...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2011
ISSN: 0165-6147
DOI: 10.1016/j.tips.2011.02.005